Our results indicate that MPS IVA chondrocytes have undergone phenotypic changes, secondary to lack of GALNS or accumulation of KS, which result in aberrant cellular function, here observed in terms of altered gene expression profile.
By using polymerase chain reaction or DNA hybridization procedures, more colonization factor specific genes and those that have undergone phenotypic changes could have been detected (13).
As we have shown in this work, the use of single surface markers for isolation of CTCs can lead to the loss of CTC populations having undergone phenotypic changes like the epithelial to mesenchymal transition.
Mechanisms of cell cycle are usually studied in cell lines in which cells have undergone phenotypic, and sometimes genetic, changes to promote extended lifespan.
It is thought that epithelial tumour cells have to undergo phenotypic changes to overcome the successive barriers to intravasation, survival in the blood, extravasation and secondary tumour formation [ 2].
To be able to disseminate from the primary tumor and metastasize, tumor cells have to undergo phenotypic changes, known as epithelial-mesenchymal transition (EMT), which allows them to travel to the site of metastasis formation without getting affected by conventional treatment.
Wanink (1998) was the first to suggest that R. argentea may have undergone rapid phenotypic changes as a result of the Nile perch introduction.
Soybean has undergone radical phenotypic changes in the seed size, colour, shattering, seed dormancy, flowering time, and plant architecture during the process of domestication.
He said Iran had undergone huge changes since the revolution.
By 2010, his life had undergone wrenching changes.
