A number of studies aiming to identify such rare variants have been conducted, and have successfully revealed several loci and genes conferring susceptibility to epilepsy, such as deletions at 15q13.3 [2] and 16p13.11 [3].
Our simple LDSS analysis has successfully revealed three distinct groups consisting of hundreds of short sequences.
Genome-wide association studies have successfully revealed risk loci for a series of cancers 16.
This technique has successfully revealed that some specific phospholipids, especially PCs, were distributed in diseased regions and adjacent non-diseased regions in pathological tissue samples [ 15– 17].
In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with disease risk, the role of common variation in partial epilepsies has not yet been explored in a well-powered study.
Selection for mutants that maintain mtDNA when mitochondrial fusion is blocked has successfully revealed mitochondrial division machinery components (Fekkes et al. 2000; Mozdy et al. 2000; Tieu and Nunnari 2000).
In the course of our studies on antioxidant, ACE inhibitory and antidiabetic activities (with α-glucosidase and DPP-4 inhibitory activity), we have successfully revealed that peptide YIEAVNKVSPRAGQF showed mild inhibitory activity against ACE (IC50 = 9.4 µg/mL).
In contrast, genome-wide association studies have successfully revealed a variety of genetic loci associated with the more common form of obesity, allowing for very strong consensus on the underlying genetic architecture of the phenotype for the first time.
The comparative mapping of Brassica by using genetic markers has successfully revealed homologous rearrangements, translocations, and fusions that are crucial to the diversification of the A, B, and C genomes from A. thaliana [ 13- 15].
Although GWAS have successfully revealed numerous susceptibility genes for neurodegenerative diseases, odds ratios associated with risk alleles are generally low and account for only a small proportion of estimated heritability.
