Sentence examples for had substantial role from inspiring English sources

In the study, mutations of p53 gene and K-ras gene codon 12, and promoter hypermethylation status of p16, RASSF1A, and APC1A gene, were also examined because these gene alterations had substantial role in pathogenesis of NSCLC and whether or not they correlated to EGFR mutations could help to further clarify the importance of EGFR mutations on pathogenesis of NSCLC.

As a child actor, Duke had substantial roles in TV movie versions of Swiss Family Robinson (1958), Meet Me in St Louis (1959) and The Power and the Glory (1961), the last starring Laurence Olivier as Graham Greene's "whiskey priest".

So I sat down with a few manufacturing experts who have either launched new consumer electronics products from scratch on their own, or have had substantial roles in them, and did nothing but ask questions.

Acute neuroinflammatory impact of BBB due to traumatic brain injury has substantial role in drug targeting, as some animal studies [ 77, 78] already found the initiation of transcriptional changes in neurovascular network for BBB breakdown that leads to neurodegeneration [ 79].

This analysis suggests that distinct regulatory imprinted small RNAs and their targets have substantial roles in human development.

The element that doesn't quite fit here is the company itself, which is devoted to works that have substantial roles for senior actors.

The only element that doesn't quite fit here is the company itself, which is made up of veteran professionals who no longer must strive to earn reputations or credits and is devoted to works that have substantial roles for senior actors.

Richard Jenkins and Bradley Whitford have substantial roles in the movie but to tell about their characters would give away some of the surprises in the plot.

Impairments in cerebral circulation and vascular reactivity have substantial roles in the onset and progression of AD/CAA in human 38 and mouse models of AD/CAA including Tg-SwDI mice.

It was suggested that distinct regulatory imprinted small RNAs such as miRNA-370 and their targets such as CHAC1 have substantial roles in cellular differentiation (Stelzer et al, 2011).

Results indicate that these factors may have substantial roles to play in the production of these lesions as the severity of pathological effects were directly proportional to the number and type of virulence factors expressed by the organism [ 13, 20].