The parental strains, FTD147 and JW135 had specific activities close to 1 μmol NADH /min /mg protein, or 16% of that of an extract of R. eutropha H16.
A minority of approved proposals referenced and had specific activities for refugees and IDPs with IDPs for HIV proposals having the highest inclusion at 19% (See figures 1 and 2).
ScASNase1 has specific activity of 196.2 U/mg and allosteric behaviour, like type I enzymes, but with a low K0.5 = 75 μM like therapeutic type II.
A chemical rescue screen identified MMV-08138 from the "Malaria Box" library of growth-inhibitory antimalarial compounds as having specific activity against the apicoplast.
In conclusion, our results show that ScASNase1 has specific activity of 196.2 U/mg, which is compatible with the enzymes used in the treatment of ALL and almost forty-fold higher than previously characterized.
The design of antimicrobial peptides could have benefited from structural studies of known peptides having specific activity against target microbes, but not toward other microorganisms.
Imatinib mesylate has specific activity in inhibiting select tyrosine kinase receptors, including platelet-derived growth factor receptors (PDGFRs) and c-kit.
On the other hand, some pycnoporus species P. sanguineus, Edible mushroom, bacteria Thermomicrobium roseum and yeast Y. lipolytica NRRL-143 have Specific activity 30, 21.92, 2.49 and 1.55 U mg−1 respectively [10, 27, 28, 29].
While the murine Mx1 protein has specific activity against orthomyxoviruses, the human MxA protein inhibits a broad spectrum of viruses (including members of the Orthomyxoviridae, Paramyxoviridae, Rhabdoviridae, Bunyaviridae, Hepadnaviridae and Asfaviridae) [7].
