However, the comparison of children with pH1N1 infections who had severe outcomes (cases) with influenza-like illness controls provides critical information to front line clinicians managing surges of children presenting with influenza-like illness during a pandemic.
Continuous exposure of the vascular endothelium to heparanase may have severe outcome.
Asthmatics were less likely than nonasthmatics to have severe outcome (11.2% versus 19.8%, unadjusted OR 0.51, 95% CI 0.36 0.72) despite a greater proportion requiring oxygen on admission (36.4% versus 26%, unadjusted OR 1.63) and similar rates of pneumonia (17.1% versus 16.6%, unadjusted OR 1.04).
Although less timely, HDD review can be a valuable surveillance tool for illnesses that frequently result in hospitalization, are rare, or have severe outcomes [ 14– 16].
Of these, 265 (83%) presented to emergency departments with Centers for Disease Control and Prevention defined symptoms of influenza-like illness and were matched with random and age matched controls with influenza-like illness who did not have severe outcomes.
This infection, which is a benign disease with a largely stable course among the general population, can have severe outcomes for immunocompromised patients, accounting for almost 90% with significant morbidity and mortality in the 8.6% of infected patients, thus highlighting the importance of pre-transplant vaccination in this subgroup of the population.
We recorded functional outcome at discharge and at 1 year, which was considered poor if the patient died, was in a state of unresponsive wakefulness, or had severe disability (Glasgow outcome scale (GOS) 1 to 3) and good if the patient had no or minimal disability (GOS 4 to 5).
Results: Of the singleton pregnancies with maternal serum human chorionic gonadotropin levels of ≥ 14 4.0 MoM, 22.5% had severe adverse obstetric outcomes, compared with only 10.9% of the matched control population (P =.001).
These viruses represent 34.8% of patients who had severe or even fatal outcome of the illness, which, however, does not quite reach statistical significance (p = 0.083).
Patient outcome was determined as favorable (patient had no, little, or moderate disability) or unfavorable (patient died, was in a vegetative state or had severe disability) using the Glasgow Outcome Scale by medical record review at 6 months after TBI.
