Sentence examples for had profound consequences on from inspiring English sources

In agreement with previous reports [8] [10], we found that knocking out pRb production in osteoblasts had profound consequences on cell adhesion, altering the expression profile of osteoblast cadherins and other cell adhesion molecules, promoting disruption of adherens junctions, and producing abnormalities in bone structure.

However the induced ablation of G9a in the background of Mili-deficiency in G9aCKO; MiliKO mice had profound consequences on the seminiferous tubules beyond those seen in the individual gene disruptions.

Introduction of an active oxidoreductase into a microorganism has profound consequences on metabolism, potentially affecting metabolic and biotransformation efficiency.

Based on these results, the ecological cost of inactivity in managing grasslands may have profound consequences on plant community stability and the wildlife that depend on them.

It's the judges who have the heavy lift: they are the ones who have to make the ultimate decisions, many of which have profound consequences on the lives of the people standing in front of them.

Together, these data indicate that AMPH alters mesocorticolimbic DA neurotransmission in a region- and receptor-specific manner, which, in turn, could have profound consequences on social behavior in female prairie voles.

The observed change in the DOM characteristics along the aquatic continuum also suggests that the terrestrial DOM pool is gradually becoming less reactive, which has profound consequences on cycling of organic carbon in aquatic ecosystems.

Dr. Collins, the chief of the National Institutes of Health, has warned that cutting the discretionary spending allocated to the N.I.H. could have profound consequences on the progression of current research and the development of future generations of scientists.

CONCLUSIONS: We show that direct interactions between betaARs and AT1Rs may have profound consequences on the overall response to drugs that antagonize these receptors.

The cuts, which amount to a minimum of at least 5% of production, would go into effect Feb. 1 and could have profound consequences on the global economy.

The development of ADAs may have profound consequences on the PK of a drug, as well as its safety and/or efficacy (Hoofring et al., 2013; Sauerborn & van Dongen, 2014).