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Thrombocytopenic patients with bleeding had platelet counts analysed twice a day.
Five additional patients with bleeding had platelet counts between 10,000 and 20,000/μL.
In the 37 women who had platelet counts of <90,000/mm3, 0 in the untreated group (0 of 11) versus 42% in the steroid group (11 of 26) received regional anesthetic, P =.015.
Of these only 20% had platelet counts below 100×10/l.
There were no cases of thrombocytopenia or thrombocytosis, all patients had platelet counts within the normal range.
At their lowest values, the patients had platelet counts of 35,000 and 22,000 (K/ml).
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Patients were excluded from the study if they had symptomatic liver disease; had platelet count <100 000 mL−1; were currently receiving ITI or prophylaxis; needed elective surgery; needed alpha-interferon or protease inhibitor use; or had previous thromboembolic events.
Moderate to severe thrombocytopenia is a common finding, with 50% of the dogs having platelet counts below 23 × 10/L.
Most patients with TMA due to malignant hypertension have platelet counts of over 50 × 10/L and hemoglobin of over 6.5 g/dl [ 16- 18].
Cytoreductive therapy should also be considered for low-risk patients who cannot tolerate phlebotomy, still have severe disease-related symptoms or progressive splenomegaly, or have platelet counts >1500 × 10/L or progressive leukocytosis [ 13].
The risk of intracerebral bleeding in critically ill patients during intensive care admission is relatively low (0.3% to 0.5%), but 88% of patients with this complication have platelet counts below 100 × 10/l [ 7].
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