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Dengue serotypes 3 and 4 had never circulated in Cuba, and we can assume low or nonexistent immunity in the population.
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Serotype Asia 1 has never circulated within Africa; serotype C has not been identified anywhere since 2005 22, 3 ).
If H7N9 becomes easily transmissible between humans, widespread transmission (due to the absence of memory B cell responses and antibody that might protect against H7, which has never circulated in human populations) and widespread illness (due to the absence of cross-reactive T cell potential) are probable.
Instead, the government seized the double eagles — an eagle was a $10 piece, a half eagle a $5 — saying that since they had never been circulated, they must have been stolen.
Much of it has previously been available only on bootlegs; some of it has never been circulated in any form.
Johnson was sentenced to just six years, and lessons from this case have never been circulated to Local Authorities.
The silver dollar had never been a popular coin, circulating little except in the West; it served as a means of monetizing metal and generally sat in bank vaults once struck.
Mr. McDonough, who described himself as a die-hard Republican, said he was finding himself doing things he had never done before, like knocking on doors and circulating petitions.
It's great, but it circulates urban legends and creates them and I had never said that......
It had been circulating in my head, this book about identity, and I had never figured out my way into it.
The works had never left the privacy of his studio, but photos snapped by neighbours had begun circulating online.
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