Sentence examples for had markedly diminished from inspiring English sources

Johnson was perhaps the last to realize that his loss to Willard (which he claimed for ever after to be a thrown fight) had markedly diminished his worth, and he had dwindling creditors to turn to.

E-PE tissues had markedly diminished HIF-1α hydroxylation at proline residues 402 and 564 as assessed with monoclonal antibodies raised against hydroxylated HIF-1α P402 or P564, suggesting regulation by PHD2 and not PHD3.

Patients were excluded if they had markedly diminished vital capacity and/or forced expiratory volume in 1 s, any serious underlying diseases or complications, or were women who were pregnant, breast feeding, or of child-bearing age.

After 24 hpi, VP1 and VPg proteins were detected in the live NV-inoculated aggregates; however, by 48 hpi, evidence for these proteins had markedly diminished and the images resembled the NV-inactivated images.

We analyzed a panel of markers and found that intrahepatic Ova Tet+CD8+ Treg cells had markedly diminished Il2 messenger RNA (mRNA) and lacked enhanced Foxp3 mRNA, but maintained elevated levels of Il10, Havcr2 (Tim-3), Pdc1 (PD-1), and Ikzf2 (Helios) mRNA, compared to Ova Tet−CD8+ T cells (Fig. 3A).

Those facts also show that confidence in and loyalty to the traditional parties of the German middle ground have markedly diminished.

While the recent upturn in form of Andy Roddick has persuaded some that he might challenge the Roger Federer-Rafael Nadal grand slam monopoly, the lack of any home player in the women's top 10 has markedly diminished any pre-tournament optimism here.

In contrast, mice genetically prone to autoimmune disease such as diabetes have markedly diminished circulating Tregs [9], [10].

S. Typhimurium strains with rpoS mutations have markedly diminished abilities to colonize the Peyer's patches in mice [24].

N-terminally degraded forms of CCL2 have markedly diminished biological activity.

Moreover, a recent in vivo study showed that CD151-null mice have markedly diminished experimental lung metastasis (Sadej et al, 2010).