First, the high rate of incarceration and attendant flood of former offenders into neighborhoods have become major impediments.
The global recession and unfavorable exchange rates have been the major impediments.
We have identified the major impediments to the success of strategies that require creation of double-strand breaks by I-SceI followed by homologous recombination to accomplish genetic changes.
We have addressed two major impediments to widespread use of genotyping by sequencing for routine use: the first is the ability to calculate unbiased estimates of the GRM using low coverage sequencing where genotypes are often missing and genotypes are probabilistic.
The contentious issue of what independence Iraqi troops will have under American command and what say the Iraqis will have in the conduct of the foreign troops had been the major impediment to agreement on the American-British draft resolution.
Failure to deliver it had become a major impediment to moving forward the peace process.
Levi Strauss's problem, he says, "isn't a problem that can be solved by a cool television campaign". In fact, he argues, the brand's mainstream, unitary, "massified" image had become a major impediment to acceptance among young consumers.
Correspondents say the question of how to define the largest bloc had been a major impediment to Mr Maliki's ambitions since his election victory in May.
A shortage of human eggs has been the major impediment to human cloning, so scientists have been trying to use animal eggs instead, a controversial approach that has raised fears of human-animal hybrids.
Adding new intrigue to the campaign, the weekend newspapers and Sunday morning talk shows focused on the sense among many political analysts that Prime Minister Gordon Brown, who is widely perceived as having led a faltering Labour campaign, has become a major impediment to Labour's chance of retaining power in a deal with the Liberal Democrats.
Despite the Punjab government which is in full support to initiate the construction of the dam, major impediments have surfaced time and again.
