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However, the mechanism of action of type I IFNs in vivo was never fully elucidated, and the pleiotropic effects of IFNs on multiple cell types had made it challenging to decipher.
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This little studied genus of small, wiry tubeworms have also been found to possesses peculiar organisation that has made it challenging to determine its position in relation to other siboglinids, have been shown to perform important ecological functions within deep-sea sediments, and is capable of colonising a multitude of reducing environments [ 25– 29, 29, 30, 34].
Twitter, meanwhile, has made it challenging for outside researchers to collect and analyze data on its platform through its public feed, the researchers said.
The same rules have made it challenging for people who work for themselves, earn money at multiple jobs or have big seasonal swings in what they earn.
The mere requirement that the District submit to a gridlocked federal legislature has made it challenging to keep the city running.
Due to the ageing population and competition from other healthcare courses, a greater demand in the healthcare workforce has made it challenging for educational institutions to attract school leavers to enter nursing courses.
The difficulties associated with acquiring, storing, and handling such vast quantities of data has made it challenging for neuroscience researchers to examine complete brains at high enough resolution to visualize all their important structures.
The need to tailor solutions to each city's context, combined with the unwieldiness of dealing with multiple stakeholders and agencies, has made it challenging for many providers to crack the smart city market and do so in a profitable way.
Several factors have made it challenging to determine the influence of genetic heterogeneity on clinical outcomes in ARDS.
However, operator involvement has made it challenging for some developers to gain easy access to location.
Strong brands have made it challenging for others, like Bank of America, to make a name in private banking without the boost that special programs can offer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com