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In concordance, patients with high CCNE protein levels had less benefit from tamoxifen in an adjuvant setting [ 27], and the overexpression of low molecular weight CCNE isoforms was associated with resistance to fulvestrant [ 28] and letrozole [ 29].
Colon cancer patients who used aspirin prediagnosis and postdiagnosis had less benefit of aspirin than postdiagnosis users, which is biologically plausible considering that tumours that developed in prediagnosis users were not prevented by aspirin use (Chan et al, 2009; Neugut, 2009).
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"We're also looking at whether adolescents who are more depressed and have more stress and poor self-esteem have less benefit in terms of their pain treatment".
Fabricant et al. [15] noted that treatment of FAI may have less benefit in patients with relative femoral retroversion.
But Liao argues that Zetia might actually make this inflammation worse and therefore may have less benefit at preventing heart attacks or even, theoretically, cause some harm.
We conclude that the molecular adjuvant C3d demonstrates utility in conditions where physiologic presentation of native protein structures is desired, but may have less benefit in the context of a relatively potent protein adjuvant such as Ribi.
We expect it would have less benefit when given to NPC patients, who are typically diagnosed after tissue damage has taken place.
Beyond 200 individuals, conserving more individuals has less benefit, and more productive action must address the rate of environmental change.
13 Our results showing a 5-year OS of 72.6 % in patients undergoing a complete cytoreduction are in line with these previous reports and demonstrate the importance of patient selection for surgery as incomplete cytoreduction has less benefit for patients.
16 Patients in the highest quarter of average centre based (not individual) time in therapeutic range may have less benefit in terms of stroke and systemic embolism with a novel drug than with warfarin.
Orthokeratology (OK) slows axial elongation of the eye by about 50% [ 14] and is the current technique with the most consistent results, except in low myopes with less than −2.00 diopters (D), in whom this therapy seems to have less benefit according to one study [ 15].
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