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A total of 13 rats with N-methyl, N-nitroso urea-induced mammary tumours were split into three courses; 6 rats were treated with epirubicin, 3 received a placebo injection and 4 had irradiation of their tumour with a direct electron beam using a single dose of 18 Gy.
Women were considered postmenopausal if they were younger than age 50 years and had natural menopause, had bilateral oophorectomy or had irradiation to the ovaries.
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They say they are also unsure about whether the findings would apply to women who have irradiation while lying prone, on their stomachs.
Except for those patients who had previous irradiation therapy, all were offered post-operative fractionated external irradiation as adjuvant treatment.
Twelve patients had undergone irradiation or radiochemo therapy before surgery through neoadjuvant treatment or therapy of former malignancies.
In all, 27 patients were treated with breast-conserving surgery and all had postoperative irradiation.
No patients had received irradiation or cancer chemotherapy prior to resection.
No patient had received irradiation treatment or chemotherapy before the resection.
Only six patients received adjuvant chemotherapy, 10 patients had adjuvant irradiation therapy.
None of the patients had received irradiation or chemotherapy before collection of specimens.
Patients who had undergone irradiation fractions >2 Gy were found to be at particular risk.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com