They also mentioned that primers might have different specificity to different variants, but their analyses did not take differences in PCR amplification efficiency into account, i.e. differences in the probability that an allele is amplified due to primer mismatches.
This distinguishes Rinl from RIN1 and suggests that different Vps9 domains have different specificity profiles for the Rab5 subfamily.
In trifunctional antibodies, the two halves of the FAb segment have different specificity: they are bispecific and trifunctional.
Generally, these two gelatinases are thought to have similar substrate specificity with respect to ECM substrates, but may have different specificity toward growth factor receptors [ 4].
In conclusion, our results raise the possibility that in general, different ARF-GEFs have different specificity of action during vesicle formation such that the same cargo protein can be delivered to different destinations.
Such a region contains all genotypes on all direct mutational paths between the molecules in a reconstructed ancestral complex and those in a descendant complex that has different specificity.
PDE4B and PDE5A have different specificity towards the cyclic nucleotide, however, both bind sildenafil (PDB ID 1TBF for PDE4B and PDB ID 1XOS for PDE5A), although PDE5A binds it with much higher affinity [ 27].
Keratin family genes, such as Keratins 7, 8, and 14, have different specificity, and some of them are reportedly expressed in cancer cells to facilitate the latter's attachment to the peritoneum, and to promote liver metastasis of some cancers.
These isoforms have been reported to have different specificities for HIF-1α and HIF-2α [10], and also differ in their subcellular localization.
The different sizes of the binding pockets and sequences of their activation function domains indicate that ERα and ERβ should have different specificities for ligands and biological responses that can be exploited for designing safer and more selective estrogens.
