We show polycistronic miRNA chromosomal clusters have common expression levels within a given cell type.
Biclustering is a technique for examining mRNA expression data and discovering genes that are conditionally co-regulated -i.e., genes that have common expression patterns under certain conditions, but not under others [ 1].
Interestingly, the PC1 score for the "long-term cultured spermatogonia" samples is similar to that of the htFibs and of the hESCs, suggesting that they have common expression of the underlying genes.
We hypothesize that the function of genes, which have common expression patterns during in planta infection and in vitro stresses, will likely represent the molecular mechanisms the fungus utilizes for successfully coping with its host environment.
In phenotypic effect-based approaches, similar drug responses may be due to the drugs affecting different targets in the same pathway or in the same biological process, rather than having common targets; also, expression patterns cannot distinguish target genes from downstream regulated genes.
However, since the two genes also have common features in gene expression and DNA-binding, they should also have similar functions in addition to their specific functions.
However, they were distributed in almost all the clusters, and have no common expression pattern with our previous study.
Besides sharing the same type of symptoms with unclear aetiology, patients with both IBS, CIPO, ED and pSS have in common expression of high serum titres of antibodies against gonadotropin-releasing hormone (GnRH) [ 3, 9- 11].
Even if a substantial proportion of these represent false discoveries, a large proportion of human genes seem to have common genetic influences on their expression level, consistent with prior surveys using sensitive allelic specific expression methods [ 6, 59].
Our results suggest that IBD, psoriasis and rheumatoid arthritis have common pathogenetic background and gene expression profiling from peripheral blood might reveal novel targets and pathways affected by these diseases.
