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LO2 cells treated in hyperosmotic medium with 500 ng/ml sTRAIL showed a 57.2% cell death rate, whereas sTRAIL FeSOD and sTRAIL mFeSOD treated with 1,000 ng/ml sTRAIL had cell death rates of 48.3% and 41.5%, respectively.
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The anti-infective agent Taurolidine (TRD) has been shown to have cell death inducing properties, but the mechanism of its action is largely unknown.
Several pathways by which mHtt may cause cell death have been identified.
Nevertheless, the precise mechanisms by which aminoglycosides cause cell death have yet to be fully elucidated.
Various metal oxide nanoparticles have shown to induce cell death after internalization [ 37, 43, 44].
Previously, the p62-positive crystallin aggregates have been shown to induce cell death.
The flasks containing a higher number of cells had faster cell death, even if the ratio of virus per cell was maintained constant in all flasks (Table 1).
Xenografts expressing wild-type Beclin 1 also had decreased cell death, as measured by the percentage of TUNEL-positive cells.
Increased fluence or CB nanoparticle concentration was also able to yield high uptake but generally had more cell death.
Older control animals had increased cell death relative to the younger controls, again demonstrating that these neurons are susceptible to age-related cell death.
Following growth of HEK293T cells over the array, the TUNEL assay was used to detect genes which had induced cell death when over-expressed.
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