Sentence examples for had caused up from inspiring English sources

One safety officer at the agency, Dr. David Graham, argued to the advisory panel that Avandia had caused up to 205,000 heart attacks and strokes since its approval in 1999.

Dr. David Graham, a drug safety officer at the federal agency, called for withdrawing the drug and estimated that its toxic effects on the heart had caused up to 205,000 heart attacks and strokes, some fatal, from 1999 to 2006.

The heatwave is also believed to have caused up to 760 deaths already and the British Red Cross has launched two call centres in Norwich and Ipswich to check on the welfare of hundreds of vulnerable people in the region.

Deadly Damage: Read "Tracking the Storm," ongoing Times coverage about all the damage Hurricane Sandy has caused up and down the Eastern Seaboard, including many deaths, millions of power failures (see video of the Manhattan Con Ed explosion on Oct. 29, above) the crane dangling over West 57th street in Manhattan, the patients who had to be evacuated from local hospitals and much more.

Mediator has been shown to cause serious heart valve problems, however, and it's now estimated to have caused up to 2000 deaths.

He leaves behind a business embroiled in scandal over a diabetes drug, Mediator, that is alleged to have caused up to 2,000 deaths.

Merck's drug Vioxx may have caused up to caused between 140,000 heart attacks in the five years the drug was on the market.

From 2011 to 2012 these 25 "billion-dollar damage" weather events in the United States are estimated to have caused up to $188 billion in total damage.

Facebook has had another privacy mishap, this time announcing a recent bug that may have caused up to 14 million users' new posts to appear publicly even if they had previously chosen a more private default setting such as "friends only".

The NoV GII.4 genotype has been the predominant genotype circulating in the US, Europe and Oceania over the past decade and has caused up to 80% of all NoV outbreaks, particularly those occurring in healthcare settings [17] [20].

None of the patients had received neoadjuvant treatment or preoperative chemotherapy or radiotherapy, which could have caused up- or downregulation of gene expression.