Hugo Lloris, Kyle Walker, Younès Kaboul, Sandro, Paulinho, Aaron Lennon and Jermain Defoe have been rested while Emmanuel Adebayor has suffered a groin strain and he joins Christian Eriksen and Danny Rose as injury casualties.
Promising left-arm seamer Topley had been rested by Essex for the game, while ex-Ireland pace bowler Rankin was with the England squad after making his first Twenty20 international appearance for them last week.
He said it was his longest action in a while, as he has been resting a bone bruise in his right wrist the past two months.
The Lions have also deprived Wales of 15 leading players, while Ryan Jones, James Hook and Paul James have been rested as Wales look to blood new talent.
Captain Cook, along with Matt Prior, Kevin Pietersen and Graeme Swann, has been rested, with vice-captain Stuart Broad leading England - while paceman Stuart Meaker has been called up to the squad as cover for the injured Steven Finn.
When you're ready to slip back into Blackberry-punching mode, at least you'll have been rested and refreshed, albeit for a little while.
The Natal-born paceman, 22, took 44 County Championship wickets in 2011, while James Anderson has been rested.
Oh, and Hatem Ben Arfa has returned to training after a hamstring injury but Alan Pardew doesn't think he's ready to start, while Davide Santon has been rested.
Dele Alli (hamstring) remains unavailable but could be in contention to face Southampton on Saturday, while Kieran Trippier has been rested.
