The glass with the highest niobium concentration, 55NaPO3 20ZnO 20Nb2O5 5Al2O3 was found to have a dissolution rate of 4.5 × 10− 8 g cm− 2 min− 1, comparable to window glass.
Although 1-D column experiments provide a fundamental understanding of the processes or parameters that govern mass transfer, it is necessary to have a dissolution model that can account for the effect of flow bypassing (Saba and Illangasekare 2000) as well as scale dependency on mass transfer (Saba 1999; Nambi and Powers 2000; Schaerlaekens and Feyen 2004).
For oral extended-release products, the guideline requires the new generic products to have a dissolution profile similar to that of the reference products in multiple test conditions (e.g., methods, medias, and rotation speeds) before undertaking a human BE study.
In vitro release and rectal absorption of quinine have been highlighted by a dialysis dissolution testing method and by the determination of bioavailability of the different formulations in rabbits.
In addition, the powders of zein-CMCS-TP/β-carotene had a fast dissolution rate and the best solubility property.
It was found that the sub-micrometer hematite powder had a relatively slow dissolution rate and required approximately 9 h to become completely dissolved in the hot oleic acid.
Furthermore, the glycerol-containing particles had a significantly lower dissolution rate (7.8% ± 2.1%, over 180 min) compared to the glycerol-free particles (58.0% ± 2.9%, over 60 min) when measured using a Franz diffusion cell.
The anodic current applied to the E2 specimen was higher than that applied to the E1 specimen during the anodization treatments, implying that the surface of the E2 specimen had a higher anodic dissolution rate than that of the E1 specimen.
