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The tragedy had a devastating effect upon many of the older composer's inner circle, many of whom later suffered nervous breakdowns.
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"We feel very strongly that moving Claire out of Wales and so far away from her family will have a devastating effect upon her and our family as a whole".
The impasse had a devastating effect.
But El Niño had a devastating effect.
The explosion had a devastating effect.
The attack has had a devastating effect on Lower Manhattan.
This has had a devastating effect on retirement policy".
Taken together it's had a devastating effect".
The Great Recession of 2008 had a devastating effect on the world economy.
"These trade pacts have had a devastating effect on every part of the state.
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