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In most CKD patients habitual sodium intake is too high, despite medical supervision.
Two studies, however, reported a significant interaction between overweight and habitual sodium intake on the risk of cardiovascular events.
Similar results were obtained with respect to the method of assessment of habitual sodium intake used in the various studies.
We used subgroup and meta-regression analyses to assess the influence of several factors on the association between habitual sodium intake and risk of stroke or cardiovascular disease.
Of note, in the latter study, habitual sodium intake was very high, that is an average of 224 mmol Na+/day.
Our meta-regression analysis indicated that the longer the follow-up the greater the effect of habitual sodium intake on the risk of stroke but not, apparently, on the risk of total cardiovascular events.
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The difference, log (AER) during treatment minus log (AER) at baseline, was modeled with a three-way ANOVA using one between-group factor (habitual dietary sodium intake) and two within-subject factors (NaCl versus placebo and telmisartan with or without HCT).
To our knowledge, comparisons of the AER and blood pressure responses to RAAS blockade and thiazide diuretic in the setting of habitual high versus low sodium intake and the addition of NaCl have not been performed in humans with or without diabetes.
Patients were classified as having a habitually high dietary salt intake (HDS) on the basis of a urinary sodium excretion >200 mmol/24 h on two out of three consecutive occasions or habitual low dietary sodium intake (LDS) with urinary sodium excretion of <100 mmol/24 h on two of three consecutive occasions.
When related to habitual salt intake, NaCl supplementation resulting in an increase in urinary sodium excretion of ∼60% mmol represents an increment in urinary sodium excretion of ∼50% in the LDS group compared with an increment of ∼25% in the HDS group.
Although two dietary recalls do not reflect true estimates of habitual intake, they do provide an upper bound of the proportion of the population meeting sodium and potassium goals.
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