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The critical sites in helix A (corresponding to residues 390 391, 393 395, 398, 401 402, 405 in H1N1 HA) fall within the R2 region identified in this study, whereas the hydrophobic interaction sites in the adjacent HA1 region (corresponding to residues 38 42, 306 307 in H1N1 HA) fall into regions R3 and R4 of this study, respectively.
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