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Gut flow was increased and oxygen transport normalized, but oxygen uptake and mucosal PO2 and pH remained low, results that were ascribed to flow redistribution from mucosal to serosal layers [ 13].
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This may improve tissue (including gut blood flow) and reduce anastomotic breakdown and reduce tissue infection.
Few studies have investigated the gastrointestinal impact of strategies to protect gut blood flow.
Enteral nutrition (EN) increases gut blood flow, thereby protecting the gastric mucosa [ 5, 6].
Early enteral feeding improves outcome in critically ill patients by increasing gut blood flow and gut function, improving wound healing and reducing septic complications.
Fg was estimated by the following equation: where Qgut and CLuG,int are the gut blood flow and unbound intrinsic clearance in the gut, respectively.
Reduced gut blood flow due to splanchnic vasoconstriction [ 1, 3] may cause hypoxic-ischaemic damage to the intestine or its mucosa predisposing to NEC.
However, there is evidence that the HABR is diminished or even abolished during endotoxaemia and when gut blood flow becomes very low.
Thus, following experimental sepsis induction we examined gut blood flow by intravital microscopy and the gut tissue perfusion by laser Doppler, in order to detect the onset of the intestinal microcirculation changes at the acute phase of sepsis.
From the therapeutical standpoint, though, it is surprising that large-volume crystalloid infusions had no major impact on total gut blood flow, DO2, and mucosal acidosis as compared with controls.
Indeed, routine gut blood flow, which is a basic requirement for effective digestion, is reduced in salmon as they swim progressively faster and can stop with abrupt stresses [ 33, 34].
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CEO of Professional Science Editing for Scientists @ prosciediting.com