Further studies should address the possibility of phagocytic cells migrating into the gut compartment in case of infection.
The equation for the gut compartment is where V gut is volume of gut; Q gut is blood flow; C a and C gut are the concentrations in arterial blood and gut compartment; and R B/P and Kp gut are the blood to plasma ratio and tissue to plasma partition coefficient.
It remains unclear how the HIV-1 reservoir in the gut compartment might be influenced by prolonged early therapy initiation, as we did not have longitudinal samples, and whether it may contribute to viral rebound after therapy interruption.
The first-order absorption model assumes instantaneous presence of the drug in the gut compartment and subsequently an exponential decrease of the absorption rate with time as dictated by the absorption rate constant, Ka.
The first-order model explains the influence by different estimates of the absorption parameter, Ka, which would suggest that metoclopramide and propantheline influence the actual uptake rate from the gut compartment.
Greater overlap of differentially expressed transcripts was observed between CD4+ and CD8+ TEM cells from the same gut compartment than between LPLs and IELs (see online supplementary figure S2).
