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Within the small intestine, Paneth cells produce and secrete into the gut antimicrobial peptides (AMPs) (17), such as α-defensins, with expression restricted to Paneth cells only in mice, as well as others.
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Probiotics may alter the local environment within the lumen of the gut, producing antimicrobial effects on pathogenic organisms.
SFB are tightly associated with the epithelium, especially in the small intestine, 38 and play a fundamental role in the maturation of intestinal T-cell responses and in the induction of gut inflammation, antimicrobial defence as well as mucosal IgA production.
Local immune responses in the gut-epithelium, including antimicrobial peptide (AMP) production [7], [8], [9], are therefore likely to be important in controlling these infections [10].
Historical evidence has shown that modulating the gut microbiota with antimicrobials leads to improved weight gain and feed efficiency in food animals [ 2].
11– 13 Rifaximin is a minimally absorbed, gut-targeted, oral antimicrobial therapy that has been evaluated in a randomised, double-blind, placebo-controlled, 6-month trial (RCT).
Reasons for the development of symptomatic infection are incompletely understood but the risk factor most commonly associated with this progression is the disruption of normal gut microbiota by antimicrobials [ 28].
Since antimicrobial peptides gut induction has been shown to depend essentially on the Imd pathway, we used relishE20 as a control.
Conversely, bile acids also regulate the gut flora via their antimicrobial activity.
Breastmilk enhances immunologic development and gut maturation, it has antimicrobial and anti-inflammatory properties [ 20].
Candida provoked extensive JNK-mediated death of gut cells and induced antimicrobial peptide expression in the fat body.
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