In addition, differentiation of cultured NSCs can be guided in vitro to yield specific neuronal subtypes for cell-based therapeutic approaches to neurodegenerative disorders.
This information combined with the knowledge that they are expressed in mouse osteoclasts can be used to guide in vitro and in vivo experiments to validate their role in bone.
An integrated approach incorporating pharmacokinetic modeling and simulation of clinical data (biliary excretion, systemic, and organ exposure) can then guide in vitro investigations to elucidate sites and mechanisms of DDIs.
Heuristic product development guided by in vitro aerosol performance testing is a costly and time-consuming process.
Here, we examined the ability of a porous poly(ε-caprolactone) (PCL) scaffold with novel bimodal-micron scale (μ-bimodal) porous architecture to promote and guide the in vitro adhesion, proliferation and three-dimensional (3-D) colonization of human mesenchymal stem cells (hMSCs).
Antimicrobial therapy should be guided by in vitro sensitivities.
Suggested treatment for M. fortuitum infection is combination therapy with at least 2 active agents as guided by in vitro susceptibilities to prevent development of resistance (27 ).
Treatment should always be guided by in vitro sensitivity testing, but first-line empiric treatment with an oral fluoroquinolone is usual, ie, ciprofloxacin 500 mg twice daily.
Overall, 70% of samples tested provided information on chemotherapy resistance, suggesting that selection of the most appropriate adjuvant therapy could be guided by in vitro results.
Instead, dose selection is guided by in vitro studies with human biomaterials, clinical experience, among other from studies in patients with hemophilia [ 3, 11- 14], and an understanding of the time course of the drug levels with dose, that is, the pharmacokinetics.
