Chemical guiding cues are being exploited to stimulate neuron adhesion and neurite outgrowth.
Chemokines are guiding cues for directional trafficking of mesenchymal stem cells (MSC) upon injury and local chemokine delivery at injury sites is an up-to-date strategy to potentiate and prolong recruitment of MSC.
Our results also suggest that endogenous calcium transients as occur during spontaneous calcium oscillations may exert a cycling resensitization-desensitization control over cell's sensing of substrate guiding cues.
Whether the resulting response is a promotion or an inhibition of locomotion will depend on how the signals are integrated during the limited sensing time window before the cell becomes adaptive to the guiding cues.
Such calcium-induced resensitization to substrate guiding cues was transient; the resensitized cells later became desensitized and moved out of the FBN path and underwent undirected migration (16 30 and 27:00).
Spontaneous cell movement is a random motion under no external guiding cues, which accompanies large fluctuations in the dynamical localizations of corresponding molecular components in order to coordinate function.
