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However, these pathways do not cease to be functionally relevant after the embryonic and early postnatal period; instead, they switch from guiding cells, to guiding synapses.
Scaffolds play a pivotal role in the tissue engineering paradigm by providing temporary structural support, guiding cells to grow, assisting the transport of essential nutrients and waste products, and facilitating the formation of functional tissues and organs.
"This is the first genetic evidence showing that electric fields play a role in guiding cells to heal wounds," says Zhao, whose team publishes its results 27 July in Nature.
Guiding cells, referred to as "guerilla cells", may provide overall orientation and direction (reviewed in [57]).
These phenomena were accompanied by increased FADD and procaspase-8 recruitment and processing, thus guiding cells toward a caspase-dependent cell death that is largely independent of the intrinsic apoptosis pathway.
The technique described herein appears to be suitable for transporting stem cells throughout the body via the blood stream and may even be a viable method for guiding cells through narrow capillaries, being a promising noninvasive and nontoxic method.
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Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm.
In designing new biomaterials, specific chemical and topographical cues will be important in guiding cell response.
However, guiding cell assembly in three-dimensional scaffolds remains a challenge.
Controlling and guiding cell behavior requires scaffolding materials capable of programming the three-dimensional (3-D) extracellular environment.
The pronounced effect of strain upon diffusivity and proteolytic susceptibility within fibrin networks offers a potentially useful means of guiding cell growth and morphology in fibrin-based biomaterials.
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