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The alignment was used to examine the conservation of guiding bar residues among the various TRs.
Additionally, a guiding bar, amino acids 407 422, has been identified in cytosolic TrxR1 but not in mitochondrial TrxR2.
It has been proposed that the guiding bar of TR1 functions to help prevent the leakage of electrons from the N-terminal redox center.
As explained in the legend of Figure 3, the guiding bar mostly restricts TR1 to utilize path A for the reduction of substrates.
This observation, combined with the proposed function of the guiding bar, fits well with the available crystal structures of human TR1, rat TR1, mouse TR3, DmTR, and PfTR enzymes.
In contrast, the guiding bar present in the TR1 enzymes from human and rat limits the motion of the C-terminal tail, allowing it to be detected in the X-ray diffraction pattern.
Similar(41)
Guide bars feed the yarn to the needles.
When the guide bar swings back to the front of the machine, the front bar has laid the thread on the hooks.
The guide bar controlled and directed retraction vectors to achieve bodily retraction of the anterior segments.
The extended guide bar directs the sliding movement in the tube (Fig. 1c, d).
One, I hate the vertical channel guide bar thing and the summer update added a traditional grid guide.
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