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As testament to this there have been multiple revisions of asthma guidelines worldwide since their inception in the late 1980s [4 6].
The evidence-based reduction in risk of microvascular disease with glucose lowering has resulted in guidelines worldwide recommending optimisation of glycosylated haemoglobin, but no trial results have shown unequivocal cardiovascular risk reduction with glucose lowering.
Whilst this association may be related to a mortality bias present in these studies, there has been an overall tendency towards a 1 1 FFP PRBC ratio in massive transfusion guidelines worldwide.
On the one hand, the SSDDEMANDED is defined based on the point mass model introduced by many design guidelines worldwide, enriched by the actual values of grade and friction variation due to the effect of vertical curves and vehicle cornering respectively.
Glutamine use is supported by clinical nutrition guidelines worldwide [ 1, 11, 15, 25].
Amongst such substances, guidelines worldwide recommend metformin as the oral antidiabetic of choice.
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Despite appropriate guidelines, healthcare services worldwide often fail to deliver high-impact evidence-based care.
To an extent, this is unsurprising, given the basic premise that steady-state analysis of flows underpins many of the codes and guidelines used worldwide.
The only detailed guidelines developed worldwide specifically for checking vibration serviceability of post-tensioned office floors have been published by the UK Concrete Society in 1994.
However, population-based studies continue to show that guidelines produced worldwide by prominent agencies for chronic and acute conditions are underused [ 3- 7].
This consensus document aims to identify barriers to guideline implementation worldwide and to define clear strategies and practice models to help overcome these barriers, focusing on the European Society of Cardiology (ESC) guidelines for the management of AF published in EP Europace in 2012.
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