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Collection was done within a clean environment to avoid the introduction of external contaminants before, during, and after the collection process, and the following guidelines were maintained to ensure the collection of a metabolically representative sample.
Similar findings were also reported by Thigpen et al (1993) who analysed a large series of patients with stage III and IV invasive epithelial ovarian cancer from six Gynecologic Oncology Group trials where strict guidelines were maintained to ensure that all patients underwent similar surgical procedures and standard adjuvant chemotherapy.
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There are publication guidance documents and checklists for standardised reporting of different types of studies (e.g. CONSORT for randomised controlled trials, STROBE for observational studies, PRISMA for systematic reviews and meta-analyses) and an updated list of reporting guidelines is maintained by the EQUATOR Network [14].
In this article, we examine the merits and risks of such collaboration even when strict universal ethical guidelines are maintained.
Some guidelines are maintained in collective databases, e.g. National Institute for Health and Clinical Excellence NICEE) [ 45] in the UK; the CBO [ 46] in the Netherlands; the German Agency for Quality in Medicine (AZQ) [ 47]; the Belgian Pallialine initiative [ 48], the National Guideline Clearing House [ 49], and the Guidelines International Network (G-I-N) [ 50].
Animals were maintained following guidelines of the Medical Research Council and in accordance with the Animals (Scientific Procedures) Act, 1986.
Cell lines were maintained per ATCC guidelines.
Athymic mice (Harlan Sprague Dawley, Indianapolis, IN) were maintained under the guidelines of the NIH and UAB.
Animals were maintained according to guidelines for the ethical use of animals in research at Hiroshima University.
Animals were maintained under the guidelines of the National Institutes of Health and Institutional Animal Care and Use Committee (IACUC) of the University of South Alabama, Mobile.
Male CD1 nude mice (Charles River, Milan, Italy) were maintained under the guidelines established by the University of L'Aquila, Medical School and Science and Technology School Board Regulations.
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