7 31 Our data show that all red flags endorsed in the guideline as "minor risk" for cancer had post-test probabilities below 3%, supporting the guideline's distinction between major risk and minor risk red flags for cancer.
An important addition to the guidelines was a distinction between low- and high-risk patients.
The current National Committee for Clinical Laboratory Standards (NCCLS) guidelines make no distinction between these two interpretations of MIC, with clinical breakpoints used to characterize most antimicrobial agents, including the fluoroquinolones.
Neither guideline makes a distinction between robust and borderline positive IGRA results.
Both sets of guidelines make a clear distinction between postmenopausal women with and without a fracture history.
Moreover, terms like "hydration," "dehydrated," and so forth are used throughout the literature on CIAKI including current guidelines without a clear distinction whether water or volume (isotonic fluid) is meant [ 1– 9].
However, we cannot yet provide precise guidelines about where this distinction occurs in biological systems, although we empirically observe that the model produces equal estimates of pool proportions across all lineages and high tree uncertainty when confronted with very highly mixed samples.
To consider this general flaw of conceptualization, new categories such as "scientifically legitimate decisions" [ 31, 32] or "justifiable guideline divergence" decisions [ 43] seem to be more appropriate to relax the rigid distinction between guideline adherence and divergence.
Second, in the literature about guideline adherence, sometimes a distinction is made between so-called 'dos' and 'don'ts'; recommendations that advise to do something and those that advise not to do something.
Where both were cited, few guidelines (n=4, 14%) made any distinction between the two systematic reviews for example, by explicitly stating that one was based on individual patient data.
