In this article, we examine the merits and risks of such collaboration even when strict universal ethical guidelines are maintained.
Some guidelines are maintained in collective databases, e.g. National Institute for Health and Clinical Excellence NICEE) [ 45] in the UK; the CBO [ 46] in the Netherlands; the German Agency for Quality in Medicine (AZQ) [ 47]; the Belgian Pallialine initiative [ 48], the National Guideline Clearing House [ 49], and the Guidelines International Network (G-I-N) [ 50].
There are publication guidance documents and checklists for standardised reporting of different types of studies (e.g. CONSORT for randomised controlled trials, STROBE for observational studies, PRISMA for systematic reviews and meta-analyses) and an updated list of reporting guidelines is maintained by the EQUATOR Network [14].
Collection was done within a clean environment to avoid the introduction of external contaminants before, during, and after the collection process, and the following guidelines were maintained to ensure the collection of a metabolically representative sample.
Similar findings were also reported by Thigpen et al (1993) who analysed a large series of patients with stage III and IV invasive epithelial ovarian cancer from six Gynecologic Oncology Group trials where strict guidelines were maintained to ensure that all patients underwent similar surgical procedures and standard adjuvant chemotherapy.
ESA management is also labor intensive and time consuming for health care providers, requiring frequent hemoglobin monitoring to ensure that guideline targets are maintained, dose changes for hemoglobin variation above guideline ranges, and depending on the ESA half-life, administration up to three times a week to maintain appropriate hemoglobin concentrations [ 23].
For programmes that aim for rabies elimination, the current 2-year guideline seems effective if control measures are maintained.
For instance, in the section of the report on the use of technology and social media, the report notes: "Though all constitutional guidelines must be maintained in the performance of law enforcement duties, the legal framework (warrants, etc).
For children more than 2 years of age the previously watchful guidelines can be maintained but some flexibility is recommended [ 22, 36].
As a guideline, platelets should be maintained at a minimum of 50,000/ μl and fibrinogen at a minimum of 50 mg/dl.
Spanish treatment guidelines recommend that SP be maintained under 4.5 mg/dL [4] and suggest to start the treatment for hyperphosphatemia, based in calcium-based phosphate binders (CB) (Calcium carbonate and calcium acetate), when dietary restrictions are insufficient [4].
