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For categorization as variation reversibility is an important criterion, but it is usually not examined in a standard guideline study.
The fact that study H was not a guideline study was stated more often when the Klimisch evaluation method was used, and more deficiencies of the study were listed.
Many of the compounds in our library have matching guideline study animal toxicity data.
We referred to the search methods of Moher et al. [ 10], and used keywords such as "guideline", "study design" in our search to identifying relevant evidence.
The candidate pVDCs were cross-referenced to ToxRefDB developmental effects [for a list of pVDCs (n = 17) without prenatal guideline study data in either species, see Supplemental Material, Table 1 (http://dx.doi.org/10.1289/ehp.1103412)].
The reasons for scepticism towards guidelines emerging in this study are comparable to barriers identified in earlier European and US studies including Langley et al's general guideline study and the recent surveys of guideline adherence among Norwegian GPs [ 3, 8, 12, 19].
Similar(53)
The data from developmental neurotoxicity (DNT) guideline studies present a number of challenges for statistical design and analysis.
The outcome of the literature review with respect to guideline studies and lipid determination methods was thus not satisfactory due to a shortage of data.
Similar changes in medication administration have been observed in other PICU guideline studies.
The EIP included three parts: guideline studies, an oral presentation, and an examination.
Because GLP is often applied to guideline toxicity studies required by regulatory mandates, it is frequently misconstrued as synonymous with guideline studies.
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