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The reverse placement idea has guided experiments on lipoxygenases for many years, especially because the product of the enzymatic reaction with linoleic acid would be the 13 S hydroperoxide for the orientation shown in Figure 1, but it would be 9 S if the substrate orientation were reversed.
This is in contrast to the traditional methodology whereby experiments are guided based on experience and intuition of chemists.
Our calculations provide a guide to experiments on the design of Ti5Si3 compounds with tailored properties.
Our calculations provide a guide to experiments on the design of 4H-SiC reinforced Al-matrix composites with tailored properties.
The results obtained in this study can serve to validate computer models of joint load transfer, to guide experiments on the mechanical regulation of chondrocyte biosynthesis, and to estimate the magnitude of deformation to be encountered by tissue-engineered cartilage within its target environment.
YC and YL proposed, designed, and guided the experiments.
LW designed and guided the experiments.
RS planned and guided sequencing experiments.
PY designed and guided the experiments and wrote the manuscript.
Bearing this in mind we are investigating a new technique, "Tomography Driven Diffraction" (TDD), that exploits tomography data to guide diffraction experiments on samples with complex structures and shapes.
It will be useful to guide future experiments on its predominance and role in the cell.
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