Sentence examples for guided design from inspiring English sources

Three example ECCs are used to illustrate the micromechanics guided design.

The obtained results will be useful for further structural guided design of MBL inhibitors.

Structure guided design was used to optimize the series resulting in a significant potency improvement.

Structure guided design was utilized to introduce kinase hinge region interacting groups in the 2-position of the scaffold.

We report herein the discovery, structure guided design, synthesis and biological evaluation of a novel class of JAK2 inhibitors.

Through a combination of X-ray co-crystal structure guided design and an in vivo screen, new substitutions in the lipophilic region of the inhibitors were identified.

Conclusion: This proof-of-principle that structure-guided design can lead to drug-like molecules affirms p7 as a much-needed new target in the burgeoning era of HCV DAA.

Together, our results support structure-guided design of inhibitory lead structures selective for immunoproteasomes that are linked to cytokine production and diseases like cancer and autoimmune disorders.

Structure activity relationship studies were carried out for lead generation following structure-guided design approach from an isocytosine scaffold identified earlier for xanthine oxidase inhibition.

These data will promote the structure-guided design of inhibitory lead structures selective for immunoproteasomes.

It is voluptuous, aggressive and feline, with crisp edges atop its fenders that speak of laser-guided design tools.