Guided by the structures of complexes of hSTING substitutions with DMXAA, we next tested additional substitutions within the ligand binding pocket to identify more constraints that would help in the design of future modifications on DMXAA.
When guided by the structure and discipline of an Environmental Management System (EMS), SMEs can engage their staff to use their skills to take actions now.
It is shown that at most two surface waves can be guided by the structure.
Rational residue substitutions were guided by the structure and properties of the binding pockets of the enzyme's active site.
Those for whom clear communication does not come easily can be guided by the structure of templates to ensure their thoughts are communicated with clarity.
Here, we report a small-molecule⋅ubiquitin-specific protease (USP) family DUB co-structure and rapid design of potent and selective inhibitors of USP7 guided by the structure.
This recursion is guided by the structure of a graph of translation tables that help compartmentalize the scope of various functions and identifier spaces, while relating these spaces for resource discovery, resolution, and routing.
It is shown that despite the presence of a characteristic length in the problem (that is, the gap width) a non-dispersive surface wave independent of the wavelength and gap width can be guided by the structure.
The modeling of the binding of Lig-D to ERK2 was guided by the structure of its complex with the yeast MAP kinase Fus3 [18] as described early.
This process is guided by the structure of the ternary complex between the target and the two fragments.
