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The design of alloy structure, guided by insight from atomic scale pcSTEM, for enhanced catalytic activity and stability, resulting from strong wetting with a deformable disordered shell, has the potential to be a general paradigm for improving catalytic performance.
To this date, clinical developments of drug combinations are typically through trial and error or guided by insight into the dysregulated signaling pathways in specific diseases.
Guided by insight from experiment, we further derived a simple linear model based on the solvent accessible surface of Ca2+ that had practically the same performance in terms of absolute errors as the more complex docking methods.
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Guided by insights obtained from numerical modeling, we have experimentally realized robust, environmentally stable laser designs that offer flexible operation performance for a wide variety of applications.
Subsequent design of the second shell of interactions guided by insights from the crystal structure on tightly bound water molecules, conformational strain, and packing defects yielded new binding partners that exhibited specificities of at least 300-fold between the cognate and the non-cognate complexes.
These problems hampered the structural modifications of H3H guided by insights from computer simulations or the crystal structures of inhibitor-bound BoNTAe complexes.
Guided by insights from these descriptive hierarchical Poisson models, we analyze the simplest population-genetic model of the neutral coalescent with an explicit accounting for heterogeneities in both mutation and recombination rates.
This study and the larger project are situated in the field of health policy and systems research (HPSR) and were guided by insights from an emerging body of literature on the social and adaptive nature of health systems [ 32, 33] and literature on micro-health systems of front-line health services [ 17, 34- 36].
Guided by this insight, we will reduce the impacts of climate change when we learn to work with nature and not against it.
Based on our previous discovery of a dual inhibitor of Mcl-1 and Bcl-2, 3-thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (1, S1), and guided by structure insight of 1 complex with Mcl-1 and Bcl-2, we exploited the spatial orientation of BH3 groove of the two proteins by a series of analogues of 1.
United by a powerful shared vision, our group has committed to work together across sectors to generate transformative change informed by the lived experiences of students and parents, guided by the insight of thoughtful educators, and scaled by innovative social entrepreneurs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com