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Understanding the genetic architecture of disease is an enormous challenge, and should be guided by evolutionary principles.
The decision, which may be reflexive or conscious, is guided by evolutionary biases based on alternative outcomes of choice, recent experience about likely conditions, and sensory information.
This is so despite the fact that those discoveries were neither predicted nor heuristically guided by evolutionary theory.
Guided by evolutionary comparisons, we hope to eventually identify all the relevant structural domains and cofactors of Hairless, thereby opening an avenue for further insights into the repressor-complexes that down-regulate Notch signaling also in other, higher eukaryotes.
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Intelligently guided by the evolutionary optimization, control engineers are able to obtain a near-optimal "off-the-computer" controller by feeding the developed CACSD system with plant I/O data and customer specifications without the need of a differentiable performance index.
Instead, their behavior is guided by deeper evolutionary goals (e.g., mating, protection, autonomy, conformity) that may deviate from rationality and are often beyond conscious control.
Guided by the evolutionary information in phylogenetic trees, Ekman et al. studied the rate of domain architecture formation and found that there are elevated rates of domain rearrangement in Metazoa [18].
Because evolution is guided by human selectors, the evolutionary algorithm is not complex.
The search for functional noncoding sequences can be guided by bioinformatic analyses combining evolutionary conservation, gene coexpression, and combinations of overrepresented short-sequence motifs.
To avoid knowledge corruption and sustain a high level of accuracy over time, an adaptive multiclassifier system (AMCS) may integrate information from diverse classifiers that are guided by a population-based evolutionary optimization algorithm.
It doesn't matter that I know that all these molecular interactions are vital for life, that I know they have been shaped and guided by the unseen hand of evolutionary selection over billions of years, or that I'm quite comfortable with my evolutionary connections to the history of life on Earth.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com