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The miRNA/siRNA duplex is unwound to a single-stranded RNA, which loads onto the RISC, and acts as a guide to recruit the silencing complex to the 3′ UTR of the target mRNA to promote translational repression or cleavage.
The retained strand acts as a guide to recruit the silencing complex mainly to the 3′ untranslated region (UTR) of target mRNA to promote translational repression16,17, with few exceptions18,19,20.
First, lncRNA acts as guide to recruit proteins to chromatin sites through RNA-DNA base pairing, to regulate downstream gene expression (Fig. 1a).
For example, HOTAIR is a scaffold for PCR2 and LSD1 as well as a guide to recruit PCR2 to target loci.
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At the mechanistic level, lncRNAs serve as "scaffolds" providing platforms to assemble RNA-protein complexes, "guides" to recruit RNAprotein complexes to target genes, and "decoys" by binding to and sequestering regulatory proteins away from their target DNA sequences [ 1, 2].
Claudio Fernández-Aráoz, a senior adviser at Egon Zehnder International and the author of Great People Decisions and "The Definitive Guide to Recruiting in Good Times and Bad," agrees that there are more benefits to hiring an overqualified employee than there are risks".When making hiring decisions, visionary leaders don't just focus on the current needs, but on the future," he says.
304 pp. ISBN: 0-12-088563-8, $69.95 To Recruit and Advance: Women Students and Faculty in U.S. Science and Engineering Committee on the Guide to Recruiting and Advancing Women Scientists and Engineers in Academia, Committee on Women in Science and Engineering, National Research Council Washington, DC:National Academies Press, 2006.
We cannot assume that all employers have HR departments to support, advise and guide them to recruit and retain their workforce.
The organizations featured in this guide are looking to recruit talented students, and some focus on working with students from underrepresented backgrounds.
It was easy, I admit, for me to recruit a guide for my visit to a Sikh temple.
"The success of her lab will depend not only on Sandrine's spectacular technical and intellectual skills but also on her ability to recruit and guide a team," Hall says.
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