As for accuracy requirement, fiducial landmarks such as on the eyes and nose need to be determined more accurately as they often guide the search for secondary landmarks with less prominent or reliable image evidence.
At present, trial data to guide the use of secondary prophylaxis for VL/HIV-1 co-infection are lacking.
In a primary care setting, Hill et al [ 27] developed a brief screening tool for identifying subgroups of patients to guide the provision of early secondary prevention in primary care.
Constraint (12) use the secondary structure to guide the sites of the components by allowing insertions if and only if one extremity overlaps or is stacked on top of a base pair.
Interestingly, postsynaptic differentiation is likely guided by the secondary vulval epithelial cells.
Ideally, ss-rRNA sequence alignments would use the conserved secondary structure to guide the primary sequence alignment.
For example, the generation of new alignments for each sequence is both computational costly, and does not take advantage of available curated alignments that make use of ss-RNA secondary structure to guide the primary sequence alignment.
In fact, MEMEris 72 uses RNA secondary structure to guide the motif search toward single-stranded regions, and PhyloGibbs 74 integrates conservation information.
PROMALS3D has advantage over conventional MSA software because it uses structural information and predicted secondary structure to guide the MSA of distantly related homolog.
Prediction accuracy of substitute decision-making is the primary outcome and rate of completed guides, the secondary outcome.
