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Although clinical development of MK-0457 has ceased, results from this and other studies that have evaluated the effects of aurora kinase inhibitors may help to guide selection and development of future anticancer agents, in combination or in select patient populations, and their use as potential chemosensitizers may be explored further.
THE BAR -- The moderately priced wine list is better than adequate, with thumbnail descriptions to guide selection and wine specials.
Real-world cases are helpful but tell us little about how and why models work (or don't), their suitability for a particular context, or how to guide selection and use.
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According to this proposal, the lateral premotor cortex is preferentially involved in externally (sensory) guided selection of movement, whereas the medial premotor cortex is primarily recruited for internally guided selection and preparation of movement.
The variable domains of MT201 were isolated from a human IgD-positive B-cell repertoire by guided selection and phage display and combined with human IgG1 constant domains as described previously (Raum et al, 2001).
Decision rules, based on research evidence, guide selection, sequencing, and dosing of elements and allow for flexibility in individual symptom presentation [ 19, 20].
Values are conceived as guiding principles in life which transcend specific situations, may change over time, guide selection of behavior and events, and which are part of dynamic system with inherent contradictions [ 1].
Knowledge of the mechanisms of DNA damage and repair may help to guide selection of chemotherapeutic agents and also may help elucidate mechanisms of resistance.
Thus, utilizing protocols that allow for selection of major endocytic mechanisms and subsequent subcellular localization have the potential to guide selection of both linker and cargo resulting in more rapid creation of effective drug conjugates of multiple subclasses.
A conceptual framework was used to guide selection of study variables and analysis.
Risk models could guide selection of priority areas and demonstrate vaccination efficacy through surveillance.
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