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The experimental results can probably guide protein formulation with a better understanding of the selection criteria for the sugar osmolytes.
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Computation is increasingly used to guide protein therapeutic designs.
Here we investigated the use of molecular dynamics (MD) simulations to determine phase system properties of polyethylenglycol (PEG phosphate systems that guide protein distribution.
Protein formulations based on crystallized proteins may have better properties than current protein formulations, such as lyophilizates or aqueous solutions.
Several approaches have been reported to stabilize protein formulations.
Silicone oil micro-droplets derived from detached lubricants are often present in protein formulations (19).
The capabilities of MFI technology for measuring protein formulations has already resulted in MFI being widely employed for sub-visible particulate analysis during formulation development.
Much larger discrepancies appear to occur in some protein formulations [ 4] and these differences may change as a function of formulation total solid content.
A constrained mixture design was adopted to guide bitumen formulation.
For the science based probability approach, experimentation is one of discovery and hypothesis testing to guide model formulation.
In this paper, the use of in vivo skin biopsy data to guide topical formulation development is described.
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