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Panel b illustrates surface dyes used to identify anatomical structures and guide microscopic evaluation.
We have developed a sequentially combined chemical imaging approach wherein an undersampled MALDI MS image is used to guide microscopic SIMS imaging experiments to target chemically interesting ROIs on the same sample.
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I spent weeks at a time swiping globs of brightly-colored paint on canvas, guided by microscopic numbers and filled with bliss.
Histologic macrodissection (samples collected from tissue sections guided by microscopic analysis of a stained serial section) provides a larger amount of sample material compared to LCM that can obviate the need for an additional round of RNA amplification.
Guided by microscopic examination of the HE stained slide, areas with at least 50% tumor cells present were grossly dissected from four 10 μm sections mounted onto glass slides, and DNA was isolated and prepared for microsatellite analysis.
For mutational profiling, DNA was extracted from cells microdissected from cytology slides guided by microscopic feature (cellular atypia when present) and from a portion of each cell-free supernatant sample that is normally discarded during preparation of cytology specimens.
It forms an important guide for future microscopic derivations of relativistic and nonrelativistic nuclear energy density functionals.
An array of 50 × 4 micro-holes, each 600 μm in diameter, was manufactured using an automatic feeding apparatus guided by a microscopic visualization system for assisted localization.
Although the biological mechanisms involved are not fully understood, grafts incorporating physical guides that mimic microscopic nerve tissue features (e.g., basal laminae) appear to provide a significant advantage over grafts that rely on purely chemical or macroscopic similarities to nerve tissue.
Correct cannula placement in the mPOA or ARC was confirmed by injection of 500 nl India ink through the internal guide cannulae followed by microscopic inspection of 30 µm frozen brain sections.
A proof-of-principle experiment was designed to test the ability of the intraoperative imaging system to guide surgical resection of microscopic residual cancer from the tumor bed.
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CEO of Professional Science Editing for Scientists @ prosciediting.com