These issues can be resolved using semi-supervised techniques or "multi-way" methods that incorporate phenotypic information to guide clustering [ 81].
We develop a scoring method to rank significant modules, and configure the algorithm to improve the search for informative modules by including a series of stopping criteria in the merge process, using modularity, module size and maximum module score to guide clustering.
Another group of researchers in [9] presented a motion planning method based on guided cluster sampling.
Leaders must now play the role of "think tank" facilitators – guiding clusters of strategic topics that roll-up to specific organizational goals and objectives.
The functional annotation of metabolites is available and could potentially be used for knowledge guided clustering.
Henceforth, we refer to the clustering based on these pairwise measures of dissimilarity as guided clustering or ClustGD.
Using a guided clustering approach Alexandra Schrader (Göttingen, Germany) showed data on gene expression modules in Burkitt lymphoma cells.
BH: Benjamini and Hochberg; ClustGD: Guided clustering; ClustUN: Unguided clustering; DE: Differentially expressed; GST: Gene set test; MM: Multiple myeloma; MRF: Multivariate random forest; miRNA: microRNA; miRmR: miRNA-mRNA; OR: Odds-ratio; PrEnrich: Percentage of clusters that are enriched.
Our guided clustering method is based on multivariate random forest (MRF) [ 17] and requires two input matrices - a Y × X miRmR map matrix and a Y × T matrix of mRNA expression values, where T denotes the number of conditions (e.g. the number of time points or patient categories).
"This report may guide future cluster headache research in another direction," the author, Dr. Rolf Salvesen of the University of Tromso in Norway, said in a statement.
