Following quality control procedures, available biological knowledge can be used to help guide both statistical and computational analyses as reviewed in Section 3. Given the complexity of the genotype phenotype mapping relationship, we recommend two complementary strategies for computational analysis.
Although this strategy would undoubtedly be impractical for general application (due to intensive computing requirements), it might be quite useful to generate a close-to-gold-standard genomic-scale orthology dataset, establishing a benchmark for future analyses, and guiding computational and biochemical investigation of ortholog structural and functional properties.
These findings provide an important guide for increasing accuracy and computational efficiency of the method.
F.P. guided the simulation design and computational data analysis, and co-wrote the paper.
Although there is no guiding principle, many experimental and computational approaches have been made.
Its results serve as testable predictions, provide insights into signal transduction and regulatory mechanisms and can guide targeted computational or experimental follow-up studies.
Similar to how geometric optics serve as fundamental principles that model how the eye optimally evolved to transform light from the natural world to form an image on the retina, my research investigates how other physical and computational primitives guide the construction of perception and action throughout higher levels of the brain.
Utilizing the known compound 6a as a starting template and guided by computational tools to derive physicochemical properties known to be important for CNS permeable drugs, the design and synthesis of a small series of novel triarylacrylonitrile analogues have been carried out providing compounds with enhanced potency and selectivity for PKC over the estrogen receptor relative to tamoxifen.
We focus on building skills in inferential thinking and computational thinking, guided by the practical questions we seek to answer.
Herein, the focus is on some recent applications that involve using theoretical and computational methods to guide the design of protein sequence ensembles, new enzymes, proteins with novel cofactors, and membrane proteins.
