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Indeed, sequential measurements of protein C levels were used to guide administration of rAPC, as reported in the phase II RESPOND trial (Research Evaluating Serial Protein C levels in severe sepsis patients on Drotrecogin alfa [activated]) [ 44, 45].
Although there is a growing body of literature on the use of viscoelastic tests to guide the administration of coagulation factor concentrates, few studies have been published on their use to guide administration of cryoprecipitate.
Most guidelines recommend that cryoprecipitate be administered in response to fibrinogen levels decreasing below a certain threshold; however, in an emergency setting, turnaround times for the Clauss fibrinogen assay are too long to effectively guide administration of haemostatic therapy in patients with acquired coagulopathic bleeding.
Similar(57)
Goal-directed haemodynamic therapies involving guided administration of intravenous fluids are associated with decreased incidence of AKI in the setting of major surgery.
Because most of these devices were not developed to guide the administration of insulin in critically ill patients, they might not be sufficiently accurate to guide therapy aimed at maintaining blood glucose within a 30-mg/dl range [ 11].
Maternal and infant clinical characteristics can help identify newborn infants who are at risk and guide the administration of empirical antibiotic therapy.
A review showed that BIS values can be used to guide the administration of general anesthetic agents in children over 2 years of age.
Part VI contains rules to guide the administration of justice.
We recommend rigorous monitoring of laboratory parameters to guide appropriate administration of blood products.
There are limited data to guide the administration of antipsychotic medication to delirious critically ill patients.
This test may be used to guide the administration of fibrinogen concentrate for prompt haemostatic therapy.
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