Sentence examples for guidance signalling from inspiring English sources

Interestingly, the most significantly dysregulated pathway in the transcriptomics dataset was Axonal Guidance Signalling.

Particularly, it highlighted possible hyper mutability of genes involved in axonal guidance signalling perhaps suggesting some evolutionary plasticity in this pathway.

Localized deactivation of CDC42 near the SLIT source results in asymmetric actin polymerization that induces the cells to migrate away from the source of SLIT, leading to repulsive guidance signalling [ 62– 62].

To explain the question raised in the beginning of this paragraph, we hypothesize that ROBO1 ROBO4 heterodimerization may prevent recruitment of srGAPs to CC3 domain of ROBO1 resulting in activation of CDC42 leading to attraction guidance signalling.

In endothelial cells, knockdown of ROBO4 abrogated the chemoattractive response to serum but enhanced chemoattractive response to SLIT2 [ 32] supporting the hypothesis, that other than SLIT, an unknown ligand may bind ROBO4 leading to activation of CDC42 and attraction guidance signalling.

These include the dopamine feedback in cAMP signaling pathway [55 57], glutamate receptor signaling [58, 59], CREB signalling in neurons [60], axonal guidance signalling, Netrin signaling [61] and nNOS signalling in neurons [62].

CeO2 impacts on axonal guidance signaling and neural stem cell differentiation.

Even in the presence of growth-promoting axon guidance signaling molecules like laminin, L1 and netrins, the higher expression of SEMA5A could inhibit retinal growth cones63.

Heatmaps of the axonal guidance signaling pathway (A), or differentiation of neurons network and differentiation of neuroglia network (B) at day 7 are illustrated.

Lipid mediators, such as sphingosine 1-phosphate (S1P), are recognized for their essential roles in spatial guidance, signaling and highly regulated endogenous gradients.

Upon examination of the axonal guidance signaling pathway heatmap at day 7 (Fig. 5A), nanoceria was found to interfere with ephrin signaling (Epha10, EphB6, EfnB1) semaphorin signaling (Sema4F, Sema3B, Sema4G, Sema4C, Sema6B), neuronal growth factor signaling (Ngf, Ngfr) as well as with β-tubulin signaling (Tubb4A, Tubb3, Tubb2A, Tubb6).