Biankin, A. V. et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.
Encapsulation of cells producing neurotrophic factors can augment axon growth and neuron survival; however, sustained innervation in vivo requires a combination of factors promoting axon growth and guidance pathway that are released in a tissue-specific context.
A guidance pathway for the selection of novel anticoagulants in the treatment of atrial fibrillation.
Here we present a general guidance pathway for the initiation and selection of oral anticoagulants in patients with AF.
These findings are consistent with SLIT and ROBO gene dysfunctions associated with autism, dyslexia, and speech sound language disorders and suggest that convergent evolution of vocal learning was associated with convergent changes in the SLIT-ROBO axon guidance pathway.
Network analysis of unique genes within the replicated pathways further revealed several interconnected functional and topologically interacting modules representing novel associations (eg, semaphoring-regulated axonal guidance pathway) besides confirming known processes (lipid metabolism).
Furthermore, the axon guidance pathway was found more active in female than male.
We observed only partial overlap of axon guidance pathway gene signatures for ALS and PD outcomes.
Hence, normal axon guidance pathway function may be of importance to develop and maintain nervous system health.
Following our 'neuronal loss' correction, two alternative pathways gained prominence: ephrin receptor signaling and the axonal guidance pathway.
However, the high model concordance and R2 values that we observed would suggest that within the available samples, axon guidance pathway gene variability played a major role.
