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The study group commented that they felt they gained more knowledge from the experience (p < 0.005) and that it was easier with ultrasound guidance (p < 0.005).
As argued by Billett (2001b): "[l]earning through participation in work can be understood in terms of how the workplace supports or inhibits individuals' engagement in work activities and access to both the direct and indirect guidance" (p. 210).
The registrars who had done ICM preliminary training for 3 months demonstrated a significant difference in being confident in inserting Central lines with Ultrasound guidance (p = 0.046) and non invasive Ventilation management (p = 0.009) than the group who did not do a formal ITU training.
The top three pathways in the meta-analysis, with their corrected p-values, were axonal guidance (p = 2.8E-07 2.8E-07 adhesion (p = 7.7E-06) and calcium signaling (p = 2.9E-05).
Other enriched functions of altered genes were calcium transport (P = 0.006), axonal guidance (P = 0.015), and Ephrin A signaling (P = 0.031).
This list includes muscle-related terms (two terms) and signal transduction/intracellular transport (25 terms), such as axon (P = 2.05E-07) axonaxon guidance (P = 2.11E-07), which may be related to muscle innervation and aging.
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A total of 2967 probes (representing 2141 genes) were DE across both development and brain regions (Supplementary Material, Table S2) and were significantly enriched for several neurodevelopmental gene ontology (GO) categories including axon guidance (nominal P = 3.4 × 10−7), neuron projection (P = 1.8 × 10−6) and synapse (P = 2.0 × 10−5).
It is enhanced by new parameters: guidance probability P guid; a local optimum detector LOD and a weight ε (used by species agents to calculate their own PSO parameters).
However, the third most enriched KEGG pathway was the axon guidance pathway (P = 2.7 × 10−10) which included 67 insertion containing genes out of a total of 73 genes in the pathway.
The Prospero/Dichaete overlaps were associated with 704 genes (Additional file 11: Table S11), including 17 genes involved in axon guidance pathways (p = 3.6E-5), as well as a collection of genes involved in the regulation of developmental processes, including cell fate commitment (106 genes, p = 3.1E-39 3.1E-39
Compared with patients in the usual care group, those in the intervention group more often received the optimal interventions such as discharge use of β-blockers, cardiac rehabilitation, pre-discharge diagnostic tests, and multidisciplinary intensive education including nurse-led patient education, pharmacist's medication teaching, and dietitian's nutritional guidance (all P < 0.05).
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